The Effect of CORT118335 on Olanzapine-Induced Weight Gain

Exclusion Criteria

• •Have received any investigational medicine in a clinical research study within the previous 3 months, or CORT118335 at any time
• •Employee, or immediate family member of a study site or Sponsor employee
• •Have a pregnant partner
• •History of abuse of any drug or alcohol, or regularly consume more than 21 units alcohol/week
• •Smokers or users of e-cigarettes and nicotine replacement products within the last 6 months
• •Clinically significant abnormal results of clinical laboratory safety tests, electrocardiogram, or measurement of heart rate and blood pressure
• •History of clinically significant cardiovascular, renal, hepatic, endocrine, metabolic, respiratory, or gastrointestinal disease, neurological or psychiatric disorder
• •History of jaundice or gallstones or had a cholecystectomy
• •Family history or known risk for narrow angle glaucoma
• •Consumed liquorice or other glycyrrhetic acid derivatives regularly in the past 6 months
• •Any condition that could be aggravated by glucocorticoid and/or mineralocorticoid antagonism (e.g., asthma, any chronic inflammatory condition, postural hypotension/orthostatic symptoms)
• •Presence or history of clinically significant allergy
• •Donation or loss of greater than 400 mL of blood within the previous 3 months
• •Are taking, or have taken, any prescribed or over-the-counter drug within 14 days other than paracetamol or standard dose multivitamins. Longer restrictions apply for some medicines.
• •Lactose intolerance.