Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency

Exclusion Criteria

• •1. Primary amenorrhea;
• •2. History of serious drug allergy or allergic constitution;
• •3. Thrombophlebitis and thromboembolia, past and present;
• •4. Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease
• •5. Autoimmune disease, history of severe familial genetic disease, etc.
• •6. Anatomical abnormality of reproductive system;
• •7. Contraindications for pregnancy;
• •8. Spouse azoospermia;
• •9. HIV+, hepatitis B, C;
• •10. Thyroid dysfunction;
• •11. History of previous malignant or ovarian tumors, history of ovarian therapy;
• •12. Abnormal karyotyping (e.g. turner syndrome, fragile X syndrome);
• •13. During pregnancy or lactation;
• •14. Alcohol or other substance abuse;
• •15. Mental disease, communicate obstruction;
• •16. Unwilling to comply with follow-up schedule or want to take other treatment during the follow-up period;
• •17. Attending doctor consider inappropriate to take part in.