A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407)-China Extension Study

Has non-squamous histology NSCLC.

Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to administration of pembrolizumab.

Before the first dose of study drug: a) Has received prior systemic cytotoxic chemotherapy for metastatic disease; b) Has received other targeted or biological antineoplastic therapy (e.g., erlotinib, crizotinib, cetuximab) for metastatic disease; c) Has had major surgery (\<3 weeks prior to first dose).

Received radiation therapy to the lung that is \>30 Gray (Gy) within 6 months of the first dose of study treatment.

Completed palliative radiotherapy within 7 days of the first dose of study treatment.

Is expected to require any other form of antineoplastic therapy while on study.

Has received a live-virus vaccination within 30 days of planned treatment start.

Has a known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for 5 years since initiation of that therapy.

Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.

Has pre-existing peripheral neuropathy that is ≥ Grade 2 by Common Terminology Criteria for Adverse Events (CTCAE) Version 4 criteria.

Previously had a severe hypersensitivity reaction to treatment with another monoclonal antibody.

Has a known sensitivity to any component of carboplatin or paclitaxel or nab-paclitaxel.

Has active autoimmune disease that has required systemic treatment in past 2 years.

Is on chronic systemic steroids.

Had prior treatment with any other anti-programmed cell death 1 (anti-PD-1), or programmed cell death ligand 1 (PD-L1) or PD-L2 agent or an antibody or a small molecule targeting other immuno-regulatory receptors or mechanisms.

Has participated in any other pembrolizumab trial and has been treated with pembrolizumab.

Has an active infection requiring therapy.

Has known history of Human Immunodeficiency Virus (HIV).

Has known active Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection.

Is, at the time of providing documented informed consent, a regular user (including "recreational use") of any illicit drugs or has a recent history (within the last year) of substance abuse (including alcohol).

Has interstitial lung disease or a history of pneumonitis that required oral or intravenous glucocorticoids to assist with management.

What this study is about