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Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis | Clinical Trials | Clareo Health

RECRUITINGNA

Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

NCT03868592•Mayo Clinic

Summary

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Detailed Description

The purpose of this study is to determine whether the adipose inflammatory cell and cytokine content in Class III obesity is related to lipolysis insulin resistance and, if so, whether sustained, substantial weight loss one year following bariatric surgery reduces inflammation in parallel with improved insulin regulation of lipolysis

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•BMI 40 - 50 kg/m2.
•Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery

Exclusion Criteria

•Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
•Active coronary artery disease
•Participation in structured exercise (\>2 times per week for 30 minutes or longer)
•Smoking
•Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
•Renal insufficiency (serum creatinine \> 1.5mg/dl)
•Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
•Pregnancy or breastfeeding.

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Key Dates

Start Date

August 1, 2019

Primary Completion Date

May 1, 2027

Completion Date

May 1, 2027

Last Updated

March 3, 2026

Enrollment

ESTIMATED participants

Conditions

Obesity, Morbid

Interventions

Gastric sleeve/bariatric surgery

PROCEDURE

Management of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery

NCT05242835

ObesityObesity, Morbid

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RECRUITINGNA

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

NCT05918575

Obesity, MorbidExtubation Failure

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 3, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Inclusion Criteria

Exclusion Criteria

Management of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Bariatric Surgery and Modulation of Perceived Satiety

Bariatric Surgery and Pharmacokinetics of Lamotrigine

Bariatric Surgery and Pharmacokinetics of Valsartan

Bariatric Surgery and Pharmacokinetics of Metoprolol