The Role of MEG in Assessment and Diagnosis In mTBI

Exclusion Criteria

• •Patient requiring hospitalisation for ≥24 hours at presentation
• •Any contraindication to undergo 7T MRI scan
• •Pregnancy
• •Other neurological, developmental or psychiatric disorders e.g. brain tumour, stroke, epilepsy, Alzheimer disease, schizophrenia, post-traumatic stress disorder, major depressive disorder, bipolar disorder or history of learning disability
• •Previous hospital attendance with TBI
• •Substance or alcohol abuse within six months of enrolment
• •Taking certain medications thought to alter MEG signals: opioids and synthetic opioids (excluding codeine and dihydrocodeine), anti-epileptic drugs, sedatives, neuroleptics, and hypnotics
• •Extensive metal dental hardware e.g. braces and large metal dentures (excluding fillings), implanted medical devices or other metal objects in the head, neck, or face areas that although they hold no risk to participants during a MEG recording may cause non-removable artefacts in the MEG data.
• •Participants who have participated in another research study involving an investigational product in the past 12 weeks.
• •Any other significant disease or disorder, which, in the opinion of the Investigator, may put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.