Fetal malformations or soft markers identified on fetal anatomy survey
Current pregnancy is a result of in vitro fertilization
Documented uterine bleeding after 24 weeks gestation. Unobserved self-reported bleeding with confirmed intact pregnancy on ultrasound after the bleeding episode is not an exclusion criterion.
* Cancer (including melanoma but excluding other skin cancers)
* Endocrine disease including thyroid disease (recently diagnosed or whose medication dose is not stable), adrenal disease, diabetes mellitus (pregestational and gestational).
* Renal disease with altered renal function (creatinine \> 0.9 or proteinuria)
* Epilepsy or other seizure disorder
* Any collagen disease (lupus erythematosus, scleroderma, etc.)
* Active liver disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes)
* Hematological disorder including alloimmune and isoimmune thrombocytopenia but excluding mild iron deficiency anemia (Hb \> 9 gm/dl). Patients with sickle cell disease are excluded.
* Chronic pulmonary disease including asthma requiring regular use of medication and active tuberculosis (TB). An asthma inhaler used on an as needed basis (PRN) for a cold or an asthma attack is not considered regular use.
* Heart disease except mitral value prolapse not requiring medication
