Helicobacter Pylori Eradication With Clostridum Butyricum Capsule and Bacillus Coagulans Tablets

Exclusion Criteria

• •1. Patients are excluded if they have previously used antibiotics to eradicate adequately recorded infection with H. pylori.
• •2. Contraindications to study drugs.
• •3. Substantial organ impairment, severe or unstable cardiopulmonary or endocrine disease.
• •4. Constant use of anti-ulcer drugs ( including taking proton-pump. inhibitors(PPI) within 2 weeks before the \[13C\] urea breath test), antibiotics or bismuth complexes (more than 3 times /1 month before screening).
• •5. Pregnant or lactating women.
• •6. Patients were diagnosed with gastroduodenal ulcer and MALT lymphoma.
• •7. Underwent upper gastrointestinal Surgery.
• •8. Patients with Barrett esophageal or highly atypical hyperplasia, have symptom of dysphagia.
• •9. Evidence of bleeding or iron efficiency anemia.
• •10. A history of malignancy.
• •11. Drug or alcohol abuse history in the past 1 year.
• •12. Systemic use of corticosteroids, non steroidal anti-inflammatory drugs, anticoagulants, platelet aggregation inhibitors (except the use of aspirin for less than 100 mg/d).
• •13. Enrolled in other clinical trials in the past 3 months.
• •14. Patients who has psychological problem or poor compliance.
• •15. Refuse to sign informed consent.