Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Florida
Age
21–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Physician-diagnosed Parkinson's disease aged 21-85 years
Hoehn \& Yahr stage \<3
Currently living in the same household with a healthy spouse/partner who meets study eligibility criteria and is willing to participate
Willing and able to complete informed consent in English
Willing to complete daily and weekly questionnaires and 6 dietary recalls over approximately 7 weeks
Willing to avoid beer, wine, and cocktails on the day before and the day of the sugar probe tests.
Willing to provide urine and stool samples during the study collection periods.
Willing and able to fast (no food or drink, except water or tea) for a prolonged period of time during study urine collections.
Willing to maintain usual diet through the pre-baseline period
Willing to make dietary changes to follow a Mediterranean dietary pattern during the intervention period.
Willing to discontinue taking prebiotic, fiber, probiotic, herbal, or high-dose vitamin or mineral supplements that may impact inflammation during the pre-baseline period and throughout the study protocol.
Willing to limit use of oral laxative medication to an "as-needed basis" (i.e. \<3 times per week) during the full length of the study
Willing to avoid high intensity exercises two days prior to and the day of the permeability tests. These tests will be done on two occasions.
Willing to provide a social security number to receive study payment.
You may not be if
Does not meet above criteria
Atypical or secondary Parkinsonism
History of deep brain stimulation
Daily use of NSAIDs in the last 3 months or incidental use in the last 2 weeks prior to screening.
Daily use of anticholinergics or prokinetic agents
Use of enemas or suppositories to alleviate constipation
Use of another investigational product within 3 months of the screening visit.
Antibiotic use within 2 months from the day of stool collection
Good adherence to the Mediterranean diet during the pre-baseline period (score \>6) based on the 14-item Mediterranean Diet Assessment Tool
Physician-diagnosed gastrointestinal disease or condition (such as ulcerative colitis, Crohn's disease, gastroparesis, cancer, peptic ulcer disease, Celiac disease, short bowel disease, ileostomy, colostomy) other than gastroesophageal reflux or diverticular disease
Clareo Health | Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease
