Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Texas Southwestern Medical Center
Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized \[1-13C\]pyruvate and \[2-13C\]pyruvate in healthy human subjects (n =10 each). Each subject will be imaged twice using the same hyperpolarized substrate with an interval (\<45min) between the injections to evaluate repeatability. Finally, eight subjects will be imaged with both hyperpolarized \[1-13C\]pyruvate and \[2-13C\]pyruvate for comparison.
Age
18–60
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
18 through 60 years of age.
Healthy, with no neurological abnormalities.
Ability to understand and the willingness to sign a written informed consent.
All races and ethnicities will be included; subjects must be able to read and speak the English language.
You may not be if
Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions
Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements
Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
Any contraindication per MRI Screening Form including
Implants contraindicated at 3T, pacemakers
Implantable Cardioverter Defibrillator (ICD)
Claustrophobia
Medically unstable including
Heart failure
Severe left ventricular outflow tract (LVOT) obstruction
