Cardio-metabolic and Inflammatory Impact of Starch Digestibility in Type 2 Diabetic Patients

Exclusion Criteria

• •Patient under legal protection measure
• •Patient deprived of liberty by a court or an administrative decision
• •Patient currently participating in another study or being in the exclusion period of another study
• •Volunteer that exceed the financial compensation allowed per year for participating in research programs
• •Gamma-GT \> 2.5 times above the norm (\>160 UI/L)
• •ASAT \> 2.5 times above the norm (\>85 UI/L)
• •ALAT \> 2.5 times above the norm (\>137.5 UI/L)
• •Triglycerides \> 4 g/L
• •LDL-cholesterol \> 1.90 g/L
• •CRP \> 15 mg/L
• •Hemoglobin \< 120 mg/dL
• •eGRF (estimated glomerular filtration rate) \< 45 ml/min
• •Other biological abnormality with clinical significant relevance according to the investigator
• •Patient with type 1 diabetes, post pancreatectomy or post transplant diabetes, MODY diabetes, mitochondrial diabetes, iatrogenic diabetes
• •T2D volunteer with any other anti-diabetic treatment other than metformin: insulin therapy, GLP-1 analogues, acarbose, sulphonylureas, repaglinide, SGLT2 agonists,…
• •Patient consuming in the two previous months regularly corticoids, beta-blocking drugs or immunosuppressing drugs
• •Patient with hemoglobin pathology
• •Patient with medical history of hemoglobinopathies (thalassemia, drepanocytosis…)
• •Patient with past bariatric surgery
• •Patient with medical history of endocrine diseases who may interfere with glucose metabolism according to the investigator (such as hyperthyroidism, acromegaly, hypercorticism…)
• •Patient treated with anticoagulants
• •Patient with a pace-maker
• •Uncontrolled high blood pressure defined by Systolic blood pressure \> 150 mmHg or Diastolic blood pressure \> 100 mmHg
• •Evidence of any other unstable or untreated clinically significant immunological, neoplasic, endocrine, haematological, gastrointestinal, hepatic, neurological or psychiatric abnormalities or medical disease with clinical significant relevance according to the investigator
• •Pregnant women or willing to become pregnant or lactating women
• •Women of childbearing age without an efficient contraceptive method according to the investigator
• •Patient under a restrictive diet or with a planned weight loss program during the study
• •Patient with severe eating disorders (e.g. anorexia nervosa, binge eating disorder and bulimia) according to the investigator
• •Patient without stable dietary habits or with specific diet (vegetarian, vegan, gluten-free…) according to the investigator
• •Patient who smokes more than 5 cigarettes per day
• •Patient regularly consuming more than 20 g/day of alcohol. Consumption of more than 3 alcoholic beverages per day is recognized as excessive. An alcoholic beverage is: 30 mL of spirituous, 120 mL of wine or 330 mL of beer
• •Patient regularly consuming recreational drugs
• •Adhesive plaster skin allergy
• •Claustrophobic patient
• •Patient willing to take the plane during the CGMS periods