Lead Sponsor

Brown University

Collaborators

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•diagnosis of MDD, assessed by the Structured Clinical Interview of DSM-5 (SCID)
•treatment-resistant, operationally defined as failure to achieve clinical remission (MADRS \<7) remit following at least one antidepressant trial in the current major depressive episode.
•Symptoms must be of at least moderate severity (MADRS score \>19)
•medications will be stable for at least six weeks prior to TMS, and there will be no dose changes unless medically necessary

•\* Standard contraindications to TMS and EEG :
•metal in the head and neck
•history of serious head injury or loss of consciousness over 10 minutes
•dementia
•seizure history
•other serious neurological disorders
•serious or unstable medical conditions that would affect EEG signal
•current severe substance use disorders (except for nicotine or caffeine)
•bipolar or psychotic-spectrum disorders (e.g., schizophrenia, schizoaffective disorder, etc.)
•Prior non-responders to TMS will also be excluded.