Translational Control of Anabolic Resistance in Aging Muscle

Exclusion Criteria

• •Cardiac abnormalities considered exclusionary by the study physician (e.g., Chronic heart Failure, right-to-left shunt)
• •Uncontrolled endocrine or metabolic disease (e.g., hypo/hyperthyroidism, diabetes)
• •History of kidney disease or failure
• •Vascular disease or risk factors of peripheral atherosclerosis. (e.g., uncontrolled hypertension, obesity, diabetes, hypercholesterolemia \> 250 mg/dl, claudication or evidence of venous or arterial insufficiency upon palpitation of femoral, popliteal and pedal arteries)
• •Risk of blood clotting including family history of thrombophilia, pulmonary emboli, myeloproliferative diseases including polycythemia (Hb\>18 g/dL) or thrombocytosis (platelets\>400x103/mL), and connective tissue diseases (positive lupus anticoagulant), hyperhomocystinemia, deficiencies of factor V Leiden, proteins S and C, and antithrombine III
• •Use of anticoagulant therapy (e.g., Coumadin, heparin)
• •Elevated systolic pressure \>150 or a diastolic blood pressure \> 100
• •Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
• •Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)
• •Currently on a weight-loss diet or body mass index \> 30 kg/m2
• •Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids are permitted). Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement is permitted)
• •History of stroke with motor disability
• •A recent history (\<12 months) of GI bleed
• •History of liver disease
• •History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
• •Prior history of Heparin-Induced Thrombocytopenia
• •An HbA1c value at or greater than 6.5%
• •Any other condition or event considered exclusionary by the PI and faculty physician