1. Provision of signed and dated informed consent form

2. Stated willingness to comply with all study procedures and availability for the duration of the study

3. Male or female, aged 18 years or older

4. Recipients of a first-time liver transplant

5. Serum Creatinine level less than 2.0 on Post-Operative Day 3-7

6. Ability to take oral medication and be willing to adhere to the assigned immunosuppression regimen

7. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration

Envarsus XL Immunosuppression Following Liver Transplantation