Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Colorado, Boulder
Age
30–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
CKD stage II-IV (eGFR using the Modification of Diet in Renal Disease (MDRD) prediction equation 20-90 mL/min/1.73m2; stable renal function in the past 3 months)
Ability to give informed consent
Albumin \> 3.0 g/dL
Ability to perform motor and cognitive tests (e.g., can rise from a chair, walk for 6 min, climb 10 stairs)
Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual of Mental Disorders (DSM-V)
Mini-mental state examination score \>21 (rationale: to screen for subjects with major cognitive impairment)
Blood pressure (BP) \>100/60 mmHg for past 3 months (rationale: blood pressure below 100/60 mmHg may elevate the normally small risk of hypotension with nitrate supplementation)
Not taking medications that will interfere with administered medications (e.g., sildenafil interacts with nitroglycerin)
Body mass index (BMI) \<40 kg/m2 (vascular function measurements can be inaccurate in severely obese patients)
You may not be if
Life expectancy \<1 year
Uncontrolled hypertension, defined as blood pressure \> 160/100 mmHg in the past 3 months
History of severe liver disease
History of severe congestive heart failure (i.e., ejection fraction \< 35%)
History of hospitalizations within the last 3 months
Active infection or antibiotic therapy
Warfarin use
Vasculitis requiring immunosuppressive therapy within the last year
High dietary nitrate intake or current nitrate/nitrite supplementation; hypersensitivity to nitrates or nitrites
Glucose-6-phosphate dehydrogenase deficiency or blood methemoglobin \>2%
Unwilling to abstain from use of mouthwash or other oral hygiene practices (e.g., tongue scraping) outside of teeth brushing that disrupt the oral microbiome and would interfere with nitrate conversion to nitrite
Blood donation within 8 weeks prior to enrolling in the study; unwilling to abstain from donating blood for 8 weeks after completing the study
