Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible

Inclusion Criteria

• •Written informed consent to participate
• •Female
• •Aged 18 years and older
• •ECOG performance status 0-2
• •Histology confirmed invasive breast cancer
• •ER positive (Allred score 6-8)
• •HER2 negative
• •Palpable size ≥20mm
• •Grade I-II (or grade III if considered not suitable for neo-adjuvant chemotherapy)
• •Considered that radiotherapy will make breast conserving surgery easier
• •No evidence of non-breast malignancy if treated with curative intent unless the patient has been disease free ≥5 years
• •Unifocal or multifocal disease, i.e. tumour in the same quadrant and breast conserving surgery still feasible