Induction Chemotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

Inclusion Criteria

• •Confirmed histological diagnosis of squamous cell carcinoma or undifferentiated carcinoma of the oropharynx, hypopharynx or larynx;
• •Locally advanced stage (stage IVa / b - AJCC 8th edition), classified as resectable \*\* or unresectable and candidate for treatment based on radiotherapy and chemotherapy;
• •Locally advanced stage (stage III - AJCC 8th edition), classified as resectable or unresectable, positive p16 and candidate for treatment based on radiotherapy and chemotherapy;
• •It will be allowed to include a patient with cervical lymphadenectomy if the primary lesion is measurable;
• •Presence of measurable disease according to RECIST 1.1 criteria;
• •ECOG performance status of 0-1;
• •≥ 18 years;
• •Adequate marrow reserve indicated by:
• •* Absolute neutrophil count (ANC) ≥ 1500 / mm³ or Platelets\> 100,000 / mm³
• •* Hemoglobin ≥ 9 g / dL - red blood cell transfusion will be allowed in the screening period if necessary
• •Adequate renal and hepatic function:
• •* Serum bilirubin ≤ 1.5 times the upper limit of normal the TGO and TGP ≤ 3 upper limit of normal. If hepatic metastasis ≤ 5 upper limit of normal
• •* Serum creatinine ≤ 1.5 mg / dL and creatinine clearance ≥ 60 mL / min calculated by Cockcroft-Gault.