Any clinical and laboratory findings that, in the judgment of the investigator, may interfere with the safety of research participants;

BP ≥ 180/110 mmHg;

Participants with BMI (body mass index) ≥ 40 Kg/m2;

Previous diagnosis of secondary hypertension;

History of Target Organ Injury;

History of cardiovascular, hepatic and renal disease;

History of gout, Diabetes Mellitus and hypokalemia;

Current medical history of cancer;

Current smoking;

History of alcohol abuse or drug use;

Pregnancy or risk of pregnancy and lactating patients;

Known allergy or hypersensitivity to the medicines components used during the clinical trial;

Participation in clinical trial in the year prior to this study.

Efficacy and Safety of Leningrado 5 Association in the Treatment of Hypertension