Systems Analysis of Antigen Presenting Cells in Human Sepsis

Exclusion Criteria

• •1. All ICU patients
• •* hematological malignancy (or significant history of bone marrow disease),
• •* HIV infection at any stage,
• •* any immunosuppressive drugs including corticosteroids ≥ 0.5 mg/kg equivalent prednisone per day for more 7 days,
• •* anticancer chemotherapy or chemotherapy received during the last three months before inclusion
• •* bone marrow or solid organ transplantation,
• •* leucopenia (\<1000/mm3) excepted if due to sepsis,
• •* pregnancy
• •* do-not-resuscitate order at ICU admission
• •* patients under legal protection regimen.
• •2. Healthy controls
• •* history of inflammatory disease
• •* hematological malignancy (or significant history of bone marrow disease),
• •* HIV infection at any stage,
• •* any immunosuppressive drugs including corticosteroids ≥ 0.5 mg/kg equivalent prednisone per day for more 7 days,
• •* anticancer chemotherapy or immunotherapy received during the last three months before inclusion
• •* bone marrow or solid organ transplantation,
• •* pregnancy
• •* infectious symptoms within the previous month
• •* subjects under legal protection regimen