WOLF - Feasibility Neurothrombectomy Study in Acute Ischemic Stroke Patients

Inclusion Criteria

• •1. Male or female subjects age ≥18 years (no upper limit).
• •2. NIHSS \> 6 at the time of baseline neuro imaging.
• •3. Endovascular treatment intended to be initiated within 60 minutes of qualifying neuroimaging and intended vessel recanalization within 90 minutes of qualifying neuroimaging.
• •4. Stroke symptom onset within 24hrs of when groin puncture can be obtained.
• •5. Anterior and posterior circulation large vessel occlusion as confirmed through neuro imaging (CT/CTA/mCTA/MRI/MRA).
• •6. Neurovascular imaging (CTA/mCTA and or MRA) must include the aortic arch, cervical vessels and intracranial circulation.
• •7. Advanced neurovascular imaging is required for patients when groin puncture can be obtained after 6 hours and before 24 hours (multiphase CTA, CT Perfusion or perfusion diffusion imaging).
• •8. The occlusion is located in a proximal intracranial artery (carotid artery, M1 segment of the MCA, or proximal M2 divisions) of the anterior circulation for patients after 6 hours and before 24 hours.
• •9. There is imaging and clinical evidence of small core and large areas at risk, defined in the previous trials (DAWN \& DEFUSE 3) as either:
• •i. NIHSS ≥10 and either 0-21 ml core infarct (≥80 years old) or 0-31 ml core infarct (\<80 years old), or NIHSS≥20 and 31 to \<51ml core infarct and \<80 years old (DAWN trial criteria).
• •OR ii. Ischemic core volume is \< 70 ml, mismatch ratio is \>/= 1.8 and mismatch volume\* is \>/= 15 ml (DEFUSE 3 trial criteria).
• •10. Pre-stroke disability limited to patients with mRS ≤ 2.
• •11. Written informed consent to participate given by subject or legal / authorized representative per local ethics committee requirements.