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External DCR Versus Canalicular SI With MMC in NLDO | Clinical Trials | Clareo Health

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External DCR Versus Canalicular SI With MMC in NLDO

External Dacryocystorhinostomy Versus Canalicular Silicone Intubation With Mitomycin C in Primary Acquired Nasolacrimal Duct Obstruction

NCT03780868•Menoufia University

View on ClinicalTrials.gov

Summary

While external DCR is the gold standard procedure for primary NLDO as well as complicated cases, SI with MMC could achieve comparable success rates in primary acquired NLDO, hence should be considered as an alternative as a safe and minimally invasive procedure.

Detailed Description

Purpose: To compare external dacryocystorhinostomy versus canalicular silicone intubation with the use of Mitomycin C (MMC) in primary acquired nasolacrimal duct obstruction (NLDO). Methods: the study was carried out at the department of Ophthalmology, Menoufia university Hospital, Egypt, between June 2012 to July 2014. Fifty-six patients who were diagnosed with primary acquired NLDO. Patients were randomly allocated into two groups: thirty cases underwent external DCR and twenty-six cases underwent silicone intubation with MMC.

Eligibility

Age

21 - 60 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•primary acquired NLDO

Exclusion Criteria

•All other secondary causes of NLDO

Key Dates

Start Date

June 1, 2012

Primary Completion Date

July 1, 2014

Completion Date

July 31, 2014

Last Updated

December 19, 2018

Enrollment

ACTUAL participants

Conditions

Primary Acquired Nasolacrimal Duct Obstruction

Interventions

external dacryocystorhinostomy

PROCEDURE

canalicular silicone intubation with MMC

PROCEDURE

Efficacy Evaluation of 5-Fluorouracil as an Adjuvant to Endoscopic Dacryocystorhinostomy in Managing Primary Acquired Nasolacrimal Duct Obstruction With Small Lacrimal Sac: A Randomized Controlled Study

NCT07154121

Primary Acquired Nasolacrimal Duct Obstruction

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 19, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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