Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Boston Pharmaceuticals
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participants are eligible to be included in the study only if all of the following criteria apply:
Male or female participants must be ≥ 18 years, at the time of signing the informed consent
Diagnosis of advanced solid tumor with a documented rearranged during transfection (RET) gene altered malignancy as determined locally by a DNA based assay of tumor tissue and/or blood
Participants must have no alternative approved therapy.
For participants in Part B expansion cohort only: documented local diagnosis of either 1) advanced RET gene fusion non-small cell lung cancer (NSCLC); 2) advanced RET gene mutant medullary thyroid cancer (MTC); or 3) other RET gene altered advanced tumors or NSCLC/MTC with prior specific RET gene targeted therapy
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Negative pregnancy test for females of child bearing potential; must be surgically sterile, postmenopausal, or willing and able to be compliant with a contraceptive regimen
Contraceptive use by men or women should be consistent with local regulations.
Capable of giving signed informed consent
Any evidence of serious active infections
Uncontrolled or severe cardiovascular disease
Uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements
Participants with a prior or concurrent malignancy other than the malignancies under study
Ongoing cancer directed therapy
You may not be if
Participants are excluded from the study if any of the following criteria apply:
Inability to take oral medications or gastrointestinal (GI) conditions that can interfere with the swallowing or absorption of study medication
Uncontrolled or severe concurrent medical condition
History of upper GI bleeding, ulceration, or perforation within 12 months prior to the first dose of study drug
Known history of stroke or cerebrovascular accident within 6 months prior to the first dose of study drug
Participants with known infection with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS) (testing not required)
Clareo Health | Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors
