Bioavailability of Phytonutrients From Novel Preparations of Broccoli

Exclusion Criteria

• •Pregnant, lactating, or intending to become pregnant during the study period
• •Women who have given birth during the previous 12 months
• •Presence of kidney disease, liver disease, gout, certain cancers, gastrointestinal disease, hyperthyroidism, untreated or unstable hypothyroidism, pancreatic disease, other metabolic diseases, or malabsorption syndromes requiring special diets
• •History of certain cancers within last 3 years
• •Known allergy or intolerance to Brassica vegetables
• •History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low-fat diets, high-protein diets)
• •Colonoscopy during three weeks prior to start of study
• •Unwillingness to abstain from probiotics or vitamin, mineral, herbal and glucosinolate/isothiocyanate supplements for two weeks prior to the study and during the study
• •Use of tobacco products within 6 months preceding study
• •Crohn's disease or diverticulitis
• •Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
• •Use of certain medications (prescription or over-the-counter) that may interfere with the study objectives
• •Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots
• •Fasting glucose greater than or equal to 126 mg/dL
• •Unable or unwilling to give informed consent or communicate with study staff
• •Self-report of alcohol or substance abuse within the past 12 months and/or current treatment for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
• •Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol