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TERMINATEDNA

Use of Beetroot Juice to Protect Against Postoperative Ileus (POI) Following Colorectal Surgery: a Pilot Study.

NCT03772444•University Hospital, Ghent

Summary

The BEET IT study investigates the possible protective effect of beetroot juice on POI following colorectal surgery in (partially) blinded single-center phase 2 randomized trial (pilot study).

Detailed Description

Postoperative ileus (POI) is a transient impairment of gastrointestinal motility following abdominal surgery, which leads to increased morbidity, prolonged hospitalization and increased healthcare cost. The pathogenesis of POI involves inflammation and oxidative stress, similar to ischemia/reperfusion injury that can be counteracted with beetroot juice. Beetroot juice is a source of inorganic nitrate, which by conversion of nitrate to nitrite in the body, exerts its protective effect. We before demonstrated in a preclinical model that administration of exogenous nitrite was shown to protect against POI. The aim of this pilot study is to investigate the possible protective effect of beetroot juice ingestion on POI following colorectal surgery.

Eligibility

Age

18 - 95 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•All patients undergoing colonic or upper rectum laparoscopic surgery.

Exclusion Criteria

•Pregnancy or breast feeding
•Psychiatric pathology capable of affecting comprehension and judgment faculty
•History of metastatic disease
•History of prior abdominal bowel surgery
•Abdominal radiation treatment
•Chronic constipation (defined as two or fewer bowel movements per week)
•Gut motility influencing agents (e.g. tricyclic antidepressants, chronic use of laxatives)
•Frequent use of mouthwash, as this affects the enterosalivary circulation of nitrate
•Current use of broad-spectrum antibiotics, which will affect the oral flora and likely affect the nitrate reductase activity
•More than one bowel anastomosis during this surgery

Locations (1)

Ghent University Hospital

Ghent, Belgium

Key Dates

Start Date

January 15, 2018

Primary Completion Date

May 25, 2019

Completion Date

May 25, 2019

Last Updated

January 20, 2023

Enrollment

ACTUAL participants

Conditions

Postoperative Ileus

Interventions

Beetroot juice

DIETARY_SUPPLEMENT

Nitrate-depleted beetroot juice

DIETARY_SUPPLEMENT

Water

DIETARY_SUPPLEMENT

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Postoperative Ileus

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COMPLETEDNA

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UNKNOWNNA

Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 20, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Use of Beetroot Juice to Protect Against Postoperative Ileus (POI) Following Colorectal Surgery: a Pilot Study.

Inclusion Criteria

Exclusion Criteria

Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery

The Effect of Coffee After Resection of Small Bowel

Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies

Ileus After Lumbar Spine Surgery

Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention

Perioperative Dexamethasone on Postoperative Outcome in IBD