Ibuprofen IV vs Acetaminophen IV for the Treatment of Pain Following Orthopaedic Low Extremity Surgery

Exclusion Criteria

• •patients with use of analgesia, muscle relaxants, NSAIDs and sedatives less than 24 hours to study drug administration
• •anemia (active, clinically significant anemia) and/or a history or evidence of asthma or heart failure
• •historical or at higher risk intracerebral bleeding, history of allergy or hypersensitive to NSAID, Ibuprofen, Acetaminophen or opioid
• •pregnant or nursing
• •body weight less than 30 kg
• •any active clinically significant bleeding or have underlying platelet dysfunction and/or receiving full dose anticoagulation therapy
• •GI bleeding that required medical intervention within the previous 6 weeks (unless definitive surgery has been performed)
• •on dialysis or renal dysfunction
• •impaired liver function
• •inability to achieve hemostasis or inability to close surgical incision prior to operating room discharge
• •operative procedure includes organ transplant, pre-and intra- operative procedure utilized for the prevention of pre- or post-operative pain (i.e, epidural or nerve blocks)
• •received anoher investigational drug within the past 30 days
• •known or suspected history of alcohol or drug abuse
• •severe infection and/or inflammatory disease