Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health

Exclusion Criteria

• •2. 65-80 years of age inclusive
• •3. Body Mass Index (BMI) between 18.5-34.9 kg/m2, inclusive
• •4. Physically inactive determined by self-report
• •5. Stable medical therapy for allowable medications for 30 days defined as:
• •1. No addition or removal of a medication
• •2. No change in dosage of a medication
• •6. Having no life-threatening conditions or diseases
• •7. Willing to allow researchers to use data, bio-specimens (blood and muscle tissue), and images (e.g., magnetic resonance imaging) for research purposes after study participation is completed
• •8. At least 2 weeks post-completion of the COVID19 vaccine regimen. a. Acceptable proof of vaccine includes a completed vaccine card and/or letter from a healthcare provider indicating the date that the COVID19 vaccine was completed.
• •1. Nursing home resident
• •2. Physically Active:
• •a. \> 100 min/wk of moderate OR \> 50 min/wk vigorous intensity PA
• •3. Saint Louis University Mental State (SLUMS) score \< 21
• •4. Evidence or self-report history of deep vein thrombosis, pulmonary embolism, cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
• •5. Evidence or self-report history of type 1 or 2 diabetes mellitus
• •6. Evidence or self-report history of a bleeding disorder
• •7. Evidence or self-report history of recurrent vasovagal episodes
• •8. Evidence or self-report history of severe depression, Schizophrenia, bipolar disease
• •9. Evidence or self-report history of mobility disability requiring a walker, wheel chair, or inability to walk across a small room.
• •10. Evidence or self-report history of orthopedic limitations that would preclude them from participation in a dynamic exercise program
• •11. Evidence or self-report history of severe arthritis (either osteoarthritis or rheumatoid arthritis) that would preclude them from participation in a dynamic exercise program
• •12. Evidence or self-report of history untreated thyroid dysfunction.
• •13. Weight loss of \> 10% in the last 3 months prior to screening
• •14. History of weight loss surgery.
• •15. Use of medications known to influence study outcomes, such as:
• •1. Insulin
• •2. Oral antidiabetic medications (e.g., metformin)
• •3. Corticosteroids
• •4. Beta-blockers
• •c. Anticoagulants
• •16. Allergy to lidocaine
• •17. Active smoking
• •18. Current consumption of \> 14 alcoholic drinks per week based on self-report
• •19. Regular participation in resistance or aerobic exercise training within 3 months of initial screening
• •20. Absolute Contraindication to Exercise as Defined by the American College of Sports Medicine,16 including:
• •1. Resting diastolic blood pressure \> 100 mm Hg
• •2. Resting systolic blood pressure \> 180 mm Hg
• •3. Resting heart rate \> 100 beats per min
• •21. Having a body weight greater than 440 pounds
• •22. Having medical implants such as a pacemaker or metal joint replacements
• •23. Having tattoos or permanent makeup completed \<30 days prior to the visit
• •24. Recent (past 3 months) cancer diagnosis, undergoing immunotherapy, taking immune suppressants
• •25. Presence of allergies or infections requiring antibiotics within the past 14 days
• •26. Recent (past 3 months) major surgery on the abdomen, pelvis, or lower extremities
• •27. Any other condition that in the judgement of the Principal Investigator and/or the Medical Director of this protocol may interfere with study participation and adherence to the protocol.
• •28. Evidence or self-report history of severe depression in the last 5 years.