Cognition and MRI Markers in MS Patients With Aubagio® Treatment

Exclusion Criteria

• •PATIENTS
• •History of neurological disease and/or other neurological diseases,
• •Psychiatric comorbidity including severe depression according to DSM-IV,
• •Alcohol or other addiction to toxic,
• •Disabling visual or motor problems preventing participation to neuropsychological assessments,
• •Acquisition disorders : Dyslexia, Dysphasia, Dyscalculia and dyspraxia,
• •Dosage change, stop or start of hypnotic or anxiolytic or antidepressive treatment less than 30 days
• •Relapse since less than one month,
• •Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily,
• •Prior neuropsychological testing with the same tests less than 6 months
• •Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI
• •Illiteracy, is unable to count or to read
• •Pregnant or breastfeeding women
• •Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)
• •HEALTHY CONTROLS
• •History of neurological disease and/or neurological diseases
• •Psychiatric comorbidity including severe depression according to DSM-IV;
• •Alcohol or other toxic addiction;
• •Known cognitive complaint or neuropsychological affection
• •Hypnotic or anxiolytic or antidepressive treatment,
• •Prior neuropsychological testing with the same tests less than 6 months
• •Acquisition disorders: Dyslexia, Dysphasia, Dyscalculia and dyspraxia,
• •Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily,
• •Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI
• •Illiteracy, is unable to count or to read
• •Pregnant or breastfeeding women
• •Person concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)