Preemptive Therapy for High Risk Chronic Lymphoid Leukemia Stage A

Exclusion Criteria

• •Binet Stage A patients with progressive disease according to International Workshop Chronic Lymphoid Leukemia 2008 criteria
• •Active secondary malignancy or chemotherapy/radiotherapy for any neoplastic disease other than Chronic Lymphoid Leukemia prior to the study
• •Medical condition requiring the long term (estimated to be more than one month) use of oral corticosteroids
• •Patient refusal to perform the bone marrow biopsy for evaluation points
• •Patients with active bacterial, viral or fungal infection
• •Subject is known to be positive for Human Immunodeficiency Virus
• •Evidence of other clinically significant uncontrolled conditions
• •Treatment with any other investigational agent or participating in another trial within 30 days prior to entering this study
• •A female patient who is pregnant or breast feeding
• •Concurrent severe diseases which exclude the administration of therapy
• •Richter's syndrome
• •Treatment with any of the following within 7 days prior to the first dose of study drug: Steroid therapy for anti-neoplastic intent, moderate or strong cytochrome P450 3A inhibitors, moderate or strong cytochrome P450 3A inducers
• •Administration or consumption of any of the following within 3 days prior to the first dose of study drug: grapefruit or grapefruit products, Seville oranges, star fruit.
• •Prior and concomitant therapy
• •Malabsorption syndrome or other condition that precludes enteral route of administration
• •Received a live viral vaccination within 6 months prior to the first dose of study drug. A significant history of renal, neurologic, psychiatric, endocrine, metabolic, immunologic, cardiovascular, or hepatic disease that, in the opinion of the investigator, would adversely affect the patient's participation in this study or interpretation of study outcomes
• •Major surgery within 30 days prior to the first dose of study treatment
• •History of prior other malignancy that could affect compliance with the protocol or interpretation of results
• •Not affiliated to social security