A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma

Inclusion Criteria

• •Previously untreated limited stage non bulky DLBCL; defined as limited stage by routine staging criteria in lymphoma involving FDG-PET and bone marrow biopsies (the Lugano criteria)\[21\]
• •Patients with grade 3B follicular lymphoma and transformed indolent lymphoma are included
• •Ages ≥ 18
• •Measurable disease, assessable by radiographic examination with FDG-PET showing involvement
• •Access to archived or fresh/frozen tumor biopsies
• •No uncontrolled medical comorbidities
• •Adequate cardiac function (EF \> or equal to 50%), no unstable angina
• •Adequate renal function (GFR \> 60)
• •Adequate liver function (liver function tests should be no greater than 2 x upper limit of normal) including normal bilirubin levels, no greater than 2 x upper limit of normal unless patient has a history of Gilbert's disease
• •Adequate marrow reserves as indicated by complete blood count in the judgment of the treating investigator