Cranial Electrotherapy Stimulation in the Treatment of Posttraumatic Stress Disorder

Exclusion Criteria

• •Participants will be excluded from participation if they meet any of the following:
• •1. Are pregnant or lactating or planning to become pregnant within the next three months;
• •2. Have a lifetime history of loss of consciousness due to head injury for greater than 10 minutes, or any lifetime history of loss of consciousness due to a head injury with documented evidence of brain injury (including brain atrophy);
• •3. Current (or past if appropriate) significant neurological disorder, or lifetime history of a) seizure disorder b) primary or secondary CNS tumors c) stroke or d) cerebral aneurysm;
• •4. Unstable medical illness, or, in the opinion of the investigator, significant absence of appropriate medical care;
• •5. Current Axis 1 primary psychotic disorder, or bipolar I disorder, active moderate/severe substance use disorders (within the last month as assessed by review of the medical records and veteran self-report, excluding nicotine/caffeine). Veterans on stable (\>3 months), monitored opiate agonist therapy may be included at the investigator's discretion;
• •6. Past failed treatment with rTMS or ECT; any past treatment with deep brain stimulation or vagus nerve stimulation;
• •7. Have active suicidal intent or plan as detected on screening assessments, or in the Investigator's opinion, is likely to attempt suicide within the next six months;
• •8. Mental retardation or cognitive impairment
• •9. History of stroke, Parkinson's Disease, Multiple Sclerosis, or seizures
• •10. Current use of Transcutaneous electrical nerve stimulation (TENS) unit
• •11. Previous history of Alpha-Stim® use
• •12. Inability to read and write in English
• •13. Incapacity to make informed medical decisions for any reason
• •15. Presence of an implanted defibrillator or pacemaker device.
• •16. Demonstrate the presence of any other condition or circumstance that, in the opinion of the investigator, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments.
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