A Phase I Study of YY-20394 in Patients With B Cell Hematologic Malignancies

Exclusion Criteria

• •1. Previously treated with PI3Kδ inhibitors and cause disease progression.
• •2. Any anti-tumor treatment, within 4 weeks prior to study entry.
• •3. There are third interstitial effusions (such as massive pleural effusion and ascites) which can not be controlled by drainage or other methods.
• •4. The dosage of steroid hormone (prednisone equivalent) was greater than 20mg/ days, and lasted for more than 14 days.
• •5. Medical history of difficulty in swallowing, malabsorption, or other chronic gastrointestinal disease, or conditions that may hamper compliance and/or absorption of the tested product.
• •6. During the study period, drugs that may prolong the QT (such as anti arrhythmic drugs) could not be interrupted.
• •7. Patients with central nervous system (CNS) involvement.
• •8. Allergy, or known to be allergic to the drug.
• •9. Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy(such as pneumonia).
• •10. Known infection with human immunodeficiency virus (HIV), hepatitis B virus(HBV), or hepatitis C virus (HCV).
• •11. History of immunodeficiency, including HIV positive test, other acquired or congenital immunodeficiency disorders, organ transplantation or allogeneic bone marrow transplantation.
• •12. Autologous hematopoietic stem cell transplantation was received within 90 days before the first dose treatment.
• •13. Has suffered from any heart disease, including: (1) angina pectoris; (2) medicated or clinically significant arrhythmia; (3) myocardial infarction; (4) heart failure; (5) any other heart disease judged by the researchers not suitable for the test.
• •14. The baseline pregnancy test was positive in pregnant women, lactating women or fertile women.
• •15. According to the judgement of the researcher, there are concomitant diseases that seriously endanger the safety of patients or affect the completion of the study (such as severe hypertension, diabetes, thyroid diseases, etc.).
• •16. Receiving granulocyte colony-stimulating factor(GCSF) or blood transfusion within 7 days before screening.
• •17. Patients suffering from other primary malignant tumors in the past 5 years.