Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
With
National Institutes of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tissues from 100 patients with endometriosis will be analyzed with droplet digital PCR (ddPCR) targeted sequencing and responders (n=50) will be compared to non-responders (n=50) after controlling confounding factors.
From a subset of the 100 cases, whole exome sequencing (WES) and Methylation-Specific PCR (MSP)-based methylation profiling on microdissected epithelium and stroma will be performed in matched eutopic and ectopic tissues from 20 patients with known cancer-associated mutations or 20 controls.
Age
18–45
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Signed informed consent.
Gender: female.
Age: 18-45 years at the time of signing consent.
Clinical or surgical diagnosis of endometriosis undergoing laparoscopy.
Controls may not have clinical or surgical diagnosis of endometriosis.
Regular menstrual cycles.
BMI between 18-40 kg/m2.
Sexually active or have had a previous vaginal exam that used a speculum.
English speaking
You may not be if
Use of any kind of steroidal therapy including oral contraceptives, Norplant, estrogen replacement/supplemental therapy, androgens (Danazol, Cyclomen, Danocrine, testosterone) or progesterone. She may not be taking or be on Celebrex.
Pregnant.
Presence of pelvic infection.
Mullerian anomalies with absence of a cervix.
History of cancer of the reproductive tract.
Presence of undiagnosed uterine bleeding.
Treatment with intrauterine device (IUD) or progestin-containing intrauterine device.
