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Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury

Changes in Doppler-derived Renal Venous Flow and Adverse Renal Outcomes Following Cardiac Surgery

NCT03753607•University of Giessen

Summary

The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).

Detailed Description

CSA-AKI is a common postoperative complication in patients undergoing open heart surgery, and is associated with increased mortality and morbidity. Venous congestion has been identified as the principal cause of cardiorenal decompensation in patients with heart failure but the relative contribution of congestion-driven renal function decline in CSA-AKI is not well studied. The prospective single-center study investigates whether serial Doppler-derived renal venous flow assessments could help identify subset of patients with cardiorenal syndrome and subclinical renal congestion at high risk of CSA-AKI.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Subjects older than 18 years
•2. Subjects undergoing elective cardiac surgery (with or without cardiopulmonary bypass)
•3. Subjects who signed informed consent forms

Exclusion Criteria

•1. Patients requiring mechanical ventilation
•2. Patients with mechanical circulatory assist devices or extracorporeal membrane oxygenation
•3. Patients with stage 3 AKI with renal replacement therapy (RRT) or life- threatening volume overload treated with RRT
•4. Stage ≥4 chronic kidney disease (CKD) stage
•5. CKD requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload, 6) 6) Prediagnosed glomerulonephritis
•6. Autosomal dominant polycystic kidney disease, postrenal obstruction, or solid organ transplantation
•7. Anticipated life expectancy of \<12 months
•8. Likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant)
•9. Pregnancy or possibility of pregnancy in the next 3 months
•10. Rhabdomyolysis

Locations (1)

University Hospital Giessen and Marburg-Campus Giessen, Department of Cardiovascular Surgery & Department of Nephrology

Giessen, Hesse, Germany

Key Dates

Start Date

December 20, 2018

Primary Completion Date

January 14, 2022

Completion Date

November 24, 2023

Last Updated

December 1, 2023

Enrollment

200

ACTUAL participants

Conditions

Acute Kidney InjuryCardiorenal Syndrome

Interventions

No intervention

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 1, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury

Inclusion Criteria

Exclusion Criteria

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