Evaluation of Safety of Repeated Doses of OP0201 Metered Dose Inhaler Compared to Placebo in Healthy Adult Volunteers

Inclusion Criteria

• •1. Body mass index of 18 to 30 kg/m2 (inclusive) and a minimum body weight of 50 kg at Screening.
• •2. Able and willing to follow study instructions (including compliance with daily study treatment administration) and likely to complete all required study visits as assessed by the Investigator's judgement.
• •3. Female subjects must agree to use an acceptable method of contraception (for pregnancy considerations and contraceptive requirements).
• •4. Female subjects who are of childbearing potential must have a negative urine pregnancy test result at Screening and Day -1 prior to randomization.
• •5. Male subjects must agree to use contraception
• •6. Subjects must agree to refrain from immersing their head fully under water (eg, swimming, diving) from the time of signed informed consent until after the study exit visit.
• •7. Physiologic tympanogram classified as Type A (normal) by the Investigator or designee.