Safety, Tolerability and Pharmacokinetics of Single Doses of TS-134 in Healthy Volunteers

Exclusion Criteria

• •Female participants who are pregnant, intend to become pregnant, or are breastfeeding
• •Clinically significant abnormal physical examination, 12-lead electrocardiogram (ECG) OR cardiac telemetry prior to dosing.
• •Significant history or presence of hepatic, renal, cardiovascular, pulmonary, gastrointestinal, hematological, locomotor, immunologic, ophthalmologic, metabolic or oncological disease.
• •History or presence of psychiatric or neurologic disease or condition
• •History of alcohol or drug abuse
• •Any participant who currently uses or has used tobacco or tobacco-containing products for at least one month prior to screening
• •Participated in strenuous exercise within 48 hours prior to study start (initial dosing) and/or are unwilling to avoid strenuous exercise at any time throughout the study.