A Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney Disease

Exclusion Criteria

• •Have urine output \<500ml per day
• •Have ESKD as a result of severe acute kidney injury (AKI) (stage 3 AKI defined by Acute Kidney Injury Network \[AKIN\]) criteria)
• •Abrupt decline in kidney function preceding HD therapy initiation (i.e., if eGFR was ≥30 mL/min/1.73 m2 3 months prior to the initiation of dialysis therapy)
• •Are scheduled to undergo transplantation from a live donor within the next 6 months
• •Have an active diagnosis of hepatorenal syndrome
• •Have a significant malignancy that is likely to impact survival
• •Have a medical condition that would jeopardize the safety of the subject.