Randomized Study of Adjuvant Radiotherapy After Curative Resection of HCC With Narrow Margin (RAISE)

Inclusion Criteria

• •1. Age 18 - 75 years.
• •2. HCC who underwent R0 resection with pathological confirmation.
• •3. The narrowest margin is less than or equal to 1 cm.
• •4. No residual tumors after surgery based on postoperative CT or MR images in 4-6 weeks.
• •5. ECOG PS ≤ 1.
• •6. Child-Pugh score 5-7.
• •7. Expected life expectancy ≥ 6 months.
• •8. Blood, liver, and kidney functions meet the following criteria: 1)Neutrophil counts ≥ 1.5×109/L; 2)Platelet counts ≥ 60×109/L; 3)Hemoglobin concentration ≥ 90g/L; 4)Serum albumin concentration ≥ 30g/L; 5)Bilirubin ≤ 1.5 × upper limit of normal; 6)AST and ALT \< 3× ULN; 7)Extended prothrombin time not exceeding 3s of ULN; 8)Creatinine \< 1.5× ULN.