Results from a CLIA approved laboratory with estimated lifetime risk of 30% or higher, based on integrated risk score that includes polygenic risk score (PRS) e.g Myriad Model.
OR
WISDOM study participant recommended to have MRI every 6 months. OR
Patients with history of chest wall radiation received before age 35. AND
Must be at least 25 years old.
Willing to travel to participating site for imaging studies as well as any necessary follow-up procedures.
Be able to give informed consent.
* Willing to travel to the University of Chicago Medicine
You may not be if
Undergoing active cancer treatment at the time of enrollment.
Current pregnancy.
Presence of a pacemaker or any other metallic foreign object in their body that interferes with an MRI.
Breast surgery within two weeks of study entry.
History of kidney disease or abnormal kidney function.
History of dye allergy unless it can be mediated with antihistamines and/or steroids
* Women can be taking hormone replacement therapy, tamoxifen, raloxifene, aromatase inhibitors, Parp Inhibitors as adjuvant therapy or participating in a chemoprevention trial.
* Women who are pregnant can return to the study after pregnancy. Expected timeframe to return back to the study after pregnancy is within 6 months post-delivery.
* Women can return to the study after being treated for early-stage breast cancer. Timing of return to the study will be per investigator's discretion.
