Ketamine for Major Depressive Disorder

Exclusion Criteria

• •A history of alcohol consumption exceeding 14 drinks/week within the 5 years before study entry.
• •Use of prescription or non-prescription drugs, vitamins, or dietary supplements within 14 days prior to the first dose of study medication except ongoing stable dose of antidepressant.
• •Treatment with any investigational drug, use of any known CYP3A4 enzyme-inducing/inhibiting agents (e.g., barbiturates, phenothiazines, cimetidine, St. John's Wort) or herbal supplements within 7 days prior to the first dose of study medication
• •A history of drug abuse or dependence within 180 days of screening
• •A febrile illness within 5 days prior to the first dose of study medication.
• •A known hypersensitivity to ketamine
• •A history of use ketamine for Major Depressive Disorder and did not respond to ketamine
• •Recent use of ketamine in any formulation for any indication (within 4 weeks prior to screening)