Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS

Exclusion Criteria

• •1. Use of medications known to affect insulin sensitivity: metformin, oral glucocorticoids within 10 days, atypical antipsychotics, immunosuppressant agents, HIV medications, hormonal contraception. Dermal patch or vaginal ring contraception methods.
• •2. Currently pregnant or breastfeeding women. Development of pregnancy during the study period will necessitate withdrawal from the study.
• •3. Severe illness requiring hospitalization within 60 days
• •4. Diabetes, defined as Hemoglobin A1C \> 6.4%
• •5. BMI percentile less than the 90th percentile for age and sex. Weight \>325 lbs or \<84 lbs.
• •6. Anemia, defined as Hemoglobin \< 11 mg/dL
• •7. Diagnosed major psychiatric or developmental disorder limiting informed consent
• •8. Implanted metal devices that are not compatible with MRI
• •9. Use of blood pressure medications
• •10. Known liver disease other than NAFLD or AST or ALT \>125 IU/L