Intra-discal Injection of PRP for Low Back Pain

Exclusion Criteria

• •\- Patient with Modic 1 discopathy in different vertebral levels
• •Patient with a Modic I signal abnormality related to a static spinal disorder (such as previous vertebral fractures, or isthmic lysis, or spondyloarthritis)
• •Patient with a history of lumbar spine surgery
• •Patient with suspected spondylodiscitis or other infection
• •Patient under anticoagulant or antiaggregant therapy, or with a coagulation disorder
• •Patient with allergy to iodine or to any of the components of Xylocaine
• •Contraindication to MRI: Pacemaker or neurosensorial stimulator or implantable defibrillator, cochlear implant, ferromagnetic foreign body similar to the nervous structure.
• •Patient with anatomical difficulty of access to the injection area (judged by the investigator)
• •Patient with an uncontrolled severe disease (i.e. heart, pulmonary, gastro-intestinal, neurologic, endocrine, auto-immune affections) limiting the patient's safety (judged by the investigator)
• •Patient with previous malignancy less than 5 years (except for non-melanoma skin cancer)
• •Prior to the screening visit:
• •a current and recent use of morphine (\< 1 month)
• •a systemic or local corticosteroid therapy (\< 1 month)
• •Porphyria
• •Patient with sphincter disorders indicating a cauda equina syndrome
• •Psychotic state not controlled by a treatment
• •Pregnancy (βHCG positive), breast-feeding or the absence of effective contraception for women of child-bearing age
• •Vulnerable persons protected by law
• •Persons under guardianship
• •Subject who are in a dependency or employment with the sponsor or the investigator
• •Participation in another clinical trial
• •Subject unable to read or/and write