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The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA) | Clinical Trials | Clareo Health

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The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)

The Analgesic Efficacy of Adding the IPACK Block to a Multimodal Analgesia Protocol for Primary Total Knee Arthroplasty

NCT03703206•University of Pennsylvania

Summary

This is a perspective, randomized, blinded study with a parallel design and an allocation ratio of 1 to 1 for the treatment groups to assess the analgesic efficacy of adding the iPACK (injection between the popliteal artery and the capsule of the knee) in addition to the adductor canal block (ACB) for Total Knee Arthoplasty patients (TKA).

Eligibility

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients scheduled for total knee arthroplasty
•American Society Anesthesiologists (ASA) physical status I- III.
•Mentally competent and able to give consent for enrollment in the study.

Exclusion Criteria

•Patient refusal,
•allergy to local anesthetics, systemic opioids (fentanyl, morphine, hydromorphone, and any of the drugs included in the multimodal perioperative pain protocol (MP3).
•Revision surgery will be excluded.
•Impaired kidney functions
•patient with coagulopathy will be also excluded.
•Chronic pain syndromes and patients with chronic opioid use in excess of a daily morphine equivalent dose (MED) of 40mg or greater for the past 3 months prior to the surgery.
•BMI of 45 or more

Locations (1)

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Key Dates

Start Date

July 1, 2018

Primary Completion Date

August 27, 2019

Completion Date

August 27, 2021

Last Updated

May 30, 2024

Enrollment

120

ACTUAL participants

Conditions

Knee Arthroplasty, Total

Interventions

ultrasound guided injection of local anesthetic between the popliteal artery and the capsule of the knee (iPACK)

DRUG

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

NCT07425457

ArthroplastyReplacement Material+4 more

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RECRUITING

Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study

NCT06847113

Knee Arthroplasty, Total

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 30, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)

Inclusion Criteria

Exclusion Criteria

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study

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Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block

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Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing