A Study to Evaluate Injection Pain and Local Tolerability Following Subcutaneous (SC) Administration of TV-46046

Exclusion Criteria

• •Participant has hypertension
• •Participant has ischemic heart disease or a history of ischemic heart disease
• •Participant has a history of stroke
• •Participant has a history of thromboembolic event(s)
• •Participant has systemic lupus erythematosus
• •Participant has rheumatoid arthritis and is undergoing immunosuppressive therapy
• •Participant has migraine with aura
• •Participant has unexplained vaginal bleeding
• •Participant has diabetes
• •Participant has a strong family history of breast cancer
• •Participant has cervical cancer or a history of cervical cancer
• •Participant has severe cirrhosis (decompensated) or liver tumors
• •Participant has known significant renal disease
• •Participant has a history of diagnosed clinical depression or bipolar disorder, with or without suicidal ideation, and/or history of suicide attempt
• •Participant is currently using hormonal contraception
• •Participant had an injection of DMPA (Depo-Provera CI or Depo-subQ 104) in the past 12 months; or combined injectable in the last 3 months
• •Participant is chronically using pain medication
• •Participant has a plan to move to another location in the next 18 months
• •* Additional criteria apply, please contact the investigator for more information