MRI Hippocampal Microstructure and Episodic Memory in Early Multiple Sclerosis

Exclusion Criteria

• •\- PATIENTS:
• •* Prior documented neurological episode suggestive of MS,
• •* History of neurological disease and/or other neurological diseases,
• •* Psychiatric diseases,
• •* Known chronic systemic diseases as judged by the investigator,
• •* Alcohol or other addiction to toxic,
• •* Disabling visual or motor problems preventing participation to neuropsychological assessments,
• •* Acquisition disorders : Dyslexia, Dysphasia, Dyscalculia and dyspraxia,
• •* Dosage change, stop or start of hypnotic or anxiolytic or antidepressive treatment less than 30 days,
• •* Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia),
• •* Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily,
• •* Illiteracy, is unable to count or to read,
• •* Pregnant or breastfeeding women,
• •* Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).
• •\- HEALTHY CONTROLS
• •* History of neurological disease and/or neurological diseases,
• •* Psychiatric diseases,
• •* Known chronic systemic diseases as judged by the investigator,
• •* Alcohol or other addiction to toxic,
• •* Acquisition disorders: Dyslexia, Dysphasia, Dyscalculia and dyspraxia,
• •* Known cognitive impairment or Prior neuropsychological testing with the same tests less than one year,
• •* Hypnotic or anxiolytic or antidepressive treatment,
• •* Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily,
• •* Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI,
• •* Illiteracy, unable to count or to read,
• •* Pregnant or breastfeeding women,
• •* Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).