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Keep this study
Lead
Springfield College
The primary aim of the proposed study is to determine whether the consumption of a prebiotic supplement (resistant starch) coupled with moderate intensity endurance training over 16 weeks leads to reductions in key inflammatory markers in stage 3-4 predialysis CKD patients and whether this reduction is associated with favorable changes in vascular function and indicators of stress and emotional reactivity.
The investigators hypothesize that supplementation with the prebiotic (resistant starch) will lead to normalization of the microbiome of our sample of patients with chronic kidney disease (CKD) and reduce key markers of inflammation. Reductions in these biomarkers will be associated with favorable changes in cardiovascular variables along with indices of stress and emotional reactivity. Moderate intensity aerobic training will have an additive anti-inflammatory effect along with the consumption of the resistant starch.
Age
30–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
stage 3-4 of CKD (GFR 15-59 ml/min/1.73m2),
ages of 30-75 years old,
Must be capable of complying with and following the study protocol(diet and exercise)
Must be capable of independently giving informed consent
You may not be if
kidney transplant
currently in a structured exercise program
on antibiotic therapy within the last month
On a probiotic or prebiotic supplement within the last month
a GI disorder that prohibits the use of resistant starch (ie. high-amylose corn starch, which resists digestion
HIV positive
gastric by-pass surgery
clostridium difficile
marijuana user
lupus
rheumatoid arthritis
Hepatitis C
Post-traumatic stress disorder
deep vein thrombosis
pancreatitis
Clareo Health | Effects of Prebiotic Supplementation and Exercise on Inflammatory Markers, Vascular Function and Cognition in CKD
