Reversing Diabetic Peripheral Neuropathy Through Exercise

Exclusion Criteria

• •Serious cardiac pathology or musculoskeletal problems that would limit exercise ability
• •MNSI score \< 1
• •Current open wound or history of plantar ulcer for the last 3 months
• •Partial foot amputations
• •Inability to ambulate without assistive device
• •Stroke or other central nervous system pathology
• •Stage 2 hypertension (resting blood pressure \>160 systolic or \>100 diastolic)
• •Contraindications to 3T whole body MRI scanners (e.g., pacemaker, cerebral aneurysm clip, cochlear implant, presence of shrapnel in strategic locations, metal in the eye, claustrophobia, or other problems).
• •Subjects with alcoholism, chronic drug use, chronic gastrointestinal disease, or renal or hepatic impairment
• •Pregnant women and children