Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Miami
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Admitted to Ryder Trauma Center for observation acutely following head injury (i.e. concussion), with documented hyposmia or anosmia by University of Pennsylvania Smell Identification Test (SIT).
Male or female, aged 18 years or older
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Ability to take oral medication and be willing to adhere to the NAC regimen
For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 4 weeks after the end of NAC administration
You may not be if
Severe trauma requiring ongoing inpatient treatment beyond 48 hours
Pregnancy (based on urine screening) or lactation
Known allergic reactions to components of NAC, such as Mucomyst
Currently taking nitrates such as nitroglycerine and/or isosorbide regularly
Currently taking azathioprine (Imuran) or cyclophosphamide (Cytoxan)
Known diagnosis of cystinuria (renal condition in which cysteine supplement should be avoided)
Febrile illness within 1 week
Treatment with another investigational drug or other intervention within 3 months
Active sinonasal disease by imaging and/or nasal exam, i.e. rhinosinusitis, nasal polyps
Adults unable to consent
Prisoners, employees or subordinates
Individuals who are not yet adults (infants, children, teenagers). This population is excluded because efficacy has not yet been established in adults.
