Effects of Sleep Disruption on Drug Response

Exclusion Criteria

• •BMI \>40
• •Significant medical or psychiatric morbidity within 6 months or lifetime history of bipolar disorder, psychotic disorder, seizure disorder
• •Lifetime history of opioid use disorder
• •Clinically significant abnormal complete blood count or comprehensive metabolic profile
• •Any contraindicated medical condition (status asthmaticus; chronic obstructive pulmonary disease; reduced respiratory function; hypotension; hypertension; impairment of hepatic, pulmonary or renal functions; myxedema or hyperthyroidism; adrenocortical insufficiency; gastrointestinal obstruction; gall bladder disease; acute alcoholism; history of convulsive disorders; history of head injury)
• •Current use of stimulants, opioids, benzodiazepines or other Central Nervous System (CNS) depressant
• •Positive toxicology screen for opioids, stimulants, or recreational drugs
• •Pregnancy or lactation
• •Significant preadmission psychological distress.
• •Report current medical/psychiatry history
• •Report acute painful injury (within 3 months)
• •Have a diagnosed chronic pain disorder.