Effects of Random Nicotine Delivery on Smoking Cessation

Exclusion Criteria

• •Unstable or significant medical conditions and conditions such as elevated blood pressure (systolic \>159 mmHg or diastolic \>99mmHg at baseline), COPD, and those conditions that are likely to affect biomarker data such as kidney or liver disease
• •Individuals with sodium-restricted diet, heart disease, recent heart attack, irregular heartbeat, stomach ulcers, or diabetes as well as those taking prescription medications for depression or asthma as indicated under "Warnings" section on FDA approved NRT Drug Facts Label
• •More than weekly use in the past 3 months of illegal drugs or prescription drugs that are not being used for medically prescribed purposes
• •Use of non-cigarette nicotine delivery product in the prior 7 days (including cigars, pipes, chew, snus, hookah, electronic cigarette and marijuana mixed with tobacco)
• •Use of an FDA approved cessation medication in the past 7 days (any NRT, Chantix, Wellbutrin)
• •Women who are pregnant (verified by urine pregnancy test at baseline visit), trying to become pregnant, or nursing
• •Uncontrolled mental illness or substance abuse or inpatient treatment for these conditions in the past 6 months
• •Any previous adverse reaction to NRT
• •Any other condition, serious illness, or situation that would, in the investigator's opinion, make it unlikely that the participant could comply with the study protocol
• •Other member of household currently participating in the study