Mediterranean Diet, Exercise and Dementia Risk in UK Adults

Exclusion Criteria

• •Diagnosis of Alzheimer's disease (AD), other form of dementia, Mild Cognitive Impairment (MCI), or significant neurological disorder
• •Cognition not within normal range, based on a score of \<26 on the Montreal Cognitive Assessment (MoCA); or an indication of cognitive decline, based on a score of ≥2 on Ascertain Dementia (AD-8)
• •Evidence of impairment of Instrumental Activities of Daily living (IADLS)
• •Moderate to severe depression, assessed by the Patient Health Questionnaire (PHQ-9), a score of \>10 being exclusionary
• •Moderate to severe anxiety, assessed by the Generalised Anxiety Disorder Assessment (GAD-7), a score of \>10 being exclusionary
• •Current psychotic illness (delusional disorder/schizophrenia)
• •History of serious mental illness know to affect cognition (schizophrenia, schizoaffective disorder, bipolar disorder)
• •Subjects with other clinically diagnosed psychiatric disorders likely to affect the cognitive measures (as judged by a clinical advisor)
• •HIV positive
• •Past history or previous MRI evidence of brain damage, significant head trauma (including loss of consciousness as a result), brain surgery, stroke, or serious neurological disorders
• •History of alcohol or drug dependency in the last 2 years
• •Subjects with existing diagnosed gastrointestinal disorders likely to impact study results (as judged by a clinical advisor)
• •History of any major cardiovascular event, such as a myocardial infarction, stroke or TIA
• •Diagnosed COPD
• •Cancer, or cancer/treatment within the last 12 months
• •Diagnosis of type 1 or type 2 diabetes \< 3 months ago
• •Clinical diagnosis of liver or kidney disease
• •Diagnosed Epilepsy
• •Subjects with any other existing medical conditions likely to affect the study measures
• •BMI \>40kg/m2
• •A habitual Mediterranean Diet Score (MDS) ≥9
• •Habitual physical activity of \>60 minutes moderate activity per week, assessed using the International Physical Activity Questionnaire (IPAQ), short form
• •Currently actively engaged in a weight loss, other dietary, or physical activity intervention
• •Prescribed medications likely to influence the study measures (as judged by a clinical advisor)
• •Currently a participant or have participated in any other study involving an investigational product in the last 4 weeks
• •Metal implants, e.g. pacemaker that precludes MRI.
• •Claustrophobic which precludes MRI scanning.