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Lidocaine Infusion for Pain After Herniotomy (LIPAH), A Randomized Placebo-controlled Trial (LIPAH Trial)
This study seeks to investigate lidocaine infusion to reduce occurrence of chronic postoperative pain at 3-month after inguinal herniotomy
Inguinal hernia repair is associated with a 5%-30% incidence of chronic pain; however, the pathogenesis remains unknown, and few studies have assessed chronic pain as the primary aim of the study. Lidocaine infusion could be a possible approach to reducing the prevalence of chronic pain after herniotomy. Recently, a meta-analysis concluded a modest but statistically significant reduction of pain severity in the first four postoperative hours measured by the visual analogue scale (mean difference, -0.84; 95% CI, -1.10 to -0.59). However, a more recent meta-analysis found that only limited clinical data and biological plausibility support lidocaine infusions for the prevention of postoperative persistent pain (odds ratio, 0.29; 95% CI, 0.18 to 0.48). This study was designed to investigate whether lidocaine infusion after inguinal herniotomy would lower the incidence of chronic postoperative pain.
Age
18 - 70 years
Sex
ALL
Healthy Volunteers
No
Guangzhou First People's Hospital
Guangzhou, Guangdong, China
Start Date
November 6, 2018
Primary Completion Date
June 30, 2019
Completion Date
June 30, 2019
Last Updated
November 7, 2018
180
ESTIMATED participants
Lidocaine
DRUG
Control
DRUG
Lead Sponsor
Guangzhou First People's Hospital
NCT06528288
NCT06879912
Data Source & Attribution
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